The One Health Center of Excellence, located in McCarty Hall D, serves as the aggregation catalyst for the rapidly expanding One Health effort at the University of Florida. The vision of the center is to capitalize on existing areas of excellence to provide innovative approaches to managing complex health issues. One Health is an interconnected approach that seeks to advance the health of humans, animals, plants, and the environment, through interdisciplinarity within and beyond the human-animal-environmental health triangle, by engaging with other disciplines including law, history, language, religion, economics, politics, sustainability, and beyond.