We are thrilled to welcome back Sofia Acevedo to our FSHN Research Journeys series, which follows the research of graduate students in the Food Science and Human Nutrition program at The University of Florida! During the first year of her nutritional sciences PhD program, Sofia investigated how spices have the potential to reduce inflammation in chronic kidney disease.

In this Research Journeys update, she discusses how her research project is focused on curcumin as a promising anti-inflammatory, her research plans going forward, and her top tips for starting a graduate program.

When we last heard from you, you were exploring the potential of spices to treat chronic inflammation. What have you discovered since then?

Over the past two years, I’ve refined my research to studying the effects of turmeric on chronic inflammation. Through a literature review on various spices and their impact on chronic disease, I found that turmeric had the strongest evidence as a potential tool for reducing inflammation. However, while studies had been conducted in adults with chronic kidney disease, the formulations used had significant limitations primarily due to turmeric’s poor natural bioavailability.

Drawing on my background in nutrition and my interest in food science, I explored different methods to enhance turmeric’s bioavailability, specifically its main bioactive component, curcumin. After testing multiple formulations and the mechanisms behind each technique, I chose to use liposomal encapsulation. My current research examines the effects of liposomal curcumin on inflammation markers in adults undergoing hemodialysis.

How has your research project changed from your first semester? Why did it change?

My research has gradually evolved through conducting preliminary studies, talking with colleagues, and reading the literature. One unexpected addition was the inclusion of a sensory evaluation component. Initially, I hadn’t planned to incorporate sensory analysis, as it falls more within the realm of food science than nutrition. However, through discussions with my committee, it became clear that assessing the sensory properties of the product used in my clinical trial was essential.

Ensuring that participants enjoyed the supplement would help maintain compliance, making the intervention more sustainable beyond financial compensation. Gathering feedback from my target population has allowed me to refine the formulation to enhance both adherence and real-world applicability.

What are the next steps with your research? What are your plans going forward?

I am currently wrapping up a clinical trial evaluating a gelatin-based protein supplement containing liposomal curcumin and its effects on inflammation markers in adults undergoing hemodialysis. Once data collection is complete, I will analyze blood samples to compare inflammation markers between the control supplement (without curcumin) and the intervention supplement (with curcumin).

This goal is the final aim of my dissertation, so once the assays are complete, I will begin analyzing my results and preparing my dissertation.

How do you relax and recharge while working on your research project?

I prioritize having hobbies and activities outside of research to help me disconnect and recharge. I try to stick to a schedule, ensuring that once my work is done for the day, I immerse myself in other activities. For physical activity, I practice martial arts, yoga, weightlifting, and Pilates—usually right after work to help me unwind and transition into the evening. After exercising, I shift to calmer hobbies like reading fiction books, painting, coloring, or exploring topics that interest me, such as music, neuroscience, psychology, and art history.

Spending time with friends, especially on weekends, is another important way I recharge. It helps me stay connected and prepares me mentally for the week ahead. If I need a break while working, particularly when dealing with a challenging problem, I take walks around campus to clear my mind and gain perspective.

What are the top three things you wish you had known going into your graduate program?

First, I wish I had known how much patience a PhD requires. It’s a marathon, not a sprint, and many aspects move slower than expected due to external factors like IRB approval, supply chain delays, and unforeseen obstacles. As someone who isn’t naturally patient, this has been one of my biggest challenges.

Second, having a strong support system is crucial. Pursuing a PhD can be isolating, especially when most of the work is independent. Many people outside academia don’t fully understand the complexities of graduate school, qualifying exams, and clinical trial logistics. Having lab mates and friends who can relate and offer support has made a huge difference in navigating the difficult moments.

Lastly, choosing an advisor who aligns with your working style and communication preferences is one of the most important decisions when selecting a graduate program. I’m incredibly grateful to have an advisor, Dr. Jeanette Andrade, who supports me not only as a PhD student but also as an individual with personal and professional aspirations. The mutual respect and trust we share have made my research experience much more positive and productive.

Looking for more posts exploring graduate research projects in the Food Science and Human Nutrition Department at the University of Florida?

Revisit Sofia’s first year in the nutritional sciences PhD program here. She is pursuing her degree under the mentorship of Dr. Jeanette Andrade.

Dive into the Research Journeys of other graduate students below.

M.S. Food Science
M.S. Nutritional Sciences
Ph.D. Food Science
Ph.D. Nutritional Sciences

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